Aquesta setmana es compleix un mes del confinament per COVID19 de la majoria d'investigadors de l'Institut Josep Carreras. Durant aquest mes les seves principals tasques s'han centrat en escriure beques i projectes, reunir i analitzar resultats, seguir tesi i investigacions d'estudiants i redactar i enviar articles. Molts dels articles escrits i enviats han estat acceptats i es publicaran en els propers mesos.

Llista d'articles que s'han publicat durant aquest mes, amb autoria principal o amb la col·laboració d'investigadors de l'Institut Josep Carreras:

Identification of 20 novel loci associated with ischaemic stroke. Epigenome-wide association study

Soriano-Tárraga C, Lazcano U, Giralt-Steinhauer E, Avellaneda-Gómez C, Ois Á, Rodríguez-Campello A, Cuadrado-Godia E, Gómez-González A, Fernández-Sanlés A, Elosua R, Fernández-Cadenas I, Cullell N, Montaner J, Moran S, Esteller M, Jiménez-Conde J, Gómez-González A.

Epigenetics. 2020 Apr 6:1-10.

doi: 10.1080/15592294.2020.1746507.

Genome-wide DNA methylation profiling in early stage I lung adenocarcinoma reveals predictive aberrant methylation in the promoter region of the long non-coding RNA PLUT - an exploratory study

Kim-Wanner SZ, Assenov Y, Nair MB, Weichenhan D, Benner A, Becker N, Landwehr K, Kuner R, Sültmann H, Esteller M, Koch I, Lindner M, Meister M, Thomas M, Bieg M, Klingmueller U, Schlesner M, Warth A, Brors B, Seifried E, Bonig H, Plass C, et al.

J Thorac Oncol. 2020 Apr 6.

doi: 10.1016/j.jtho.2020.03.023

Scute myeloid leukemia with inv(3)(q21q26.2)/t(3;3)(q21;q26.2). study of 61 patients treated with intensive protocols

Sitges M, Boluda B, Garrido A, Morgades M, Granada I, Barragan E, Arnan M, Serrano J, Tormo M, Miguel Bergua J, Colorado M, Salamero O, Esteve J, Benavente C, Pérez-Encinas M, Coll R, Martí-Tutusaus JM, Brunet S, Sierra J, Ángel Sanz M, Montesinos P, Ribera JM, et al.

Eur J Haematol. 2020 Apr 3.

doi: 10.1111/ejh.13417.

H3K79me2/3 controls enhancer-promoter interactions and activation of the pan-cancer stem cell marker PROM1/CD133 in MLL-AF4 leukemia cells

Godfrey L, Crump NT, O'Byrne S, Lau IJ, Rice S, Harman JR, Jackson T, Elliott N, Buck G, Connor C, Thorne R, Knapp DJHF, Heidenreich O, Vyas P, Menendez P, Inglott S, Ancliff P, Geng H, Roberts I, Roy A, Milne TA.

Leukemia. 2020 Apr 2.

doi: 10.1038/s41375-020-0808-y.

Disruption of the RNA modifications that target the ribosome translation machinery in human cancer

Janin M, Coll-SanMartin L, Esteller M.

Mol Cancer. 2020 Apr 2;19(1):70.

doi: 10.1186/s12943-020-01192-8.

Understanding oncogenicity of cancer driver genes and mutations in the cancer genomics era.

Porta-Pardo E, Valencia A, Godzik A.

FEBS Lett. 2020 Apr 1.

doi: 10.1002/1873-3468.13781

A lncRNA Decoy Predicts Sensitivity to Cisplatin

Boque-Sastre R, Guil S.

Trends Mol Med. 2020 Apr; 26(4):352-354.

doi: 10.1016/j.molmed.2020.01.015.

Mechanisms of epigenetic inheritance of variable traits through the germline

Eduard Casas and Tanya Vavouri. Reproduction Journal. Page(s): R251–R263Volume/Issue: Volume 159: Issue 6. Apr 2020 DOI:https://doi.org/10.1530/REP-19-0340

Epigenetic footprint enables molecular risk stratification of hepatoblastoma with clinical implications

Carrillo-Reixach J, Torrens L, Simon-Coma M, Royo L, Domingo-Sàbat M, Abril-Fornaguera J, Akers N, Sala M, Ragull S, Arnal M, Villalmanzo N, Cairo S, Villanueva A, Kappler R, Garrido M, Guerra L, Sábado C, Guillén G, Mallo M, Piñeyro D, Vázquez-Vitali M, Kuchuk O, et al.

J Hepatol. 2020 Mar 30.

doi: 10.1016/j.jhep.2020.03.025.

A critical evaluation of pembrolizumab in addition to lenalidomide and dexamethasone for the treatment of multiple myeloma

Oriol A.

Expert Rev Hematol. 2020 Mar 21:1-11.

doi: 10.1080/17474086.2020.1744432.

Granulocytic sarcoma: Study of two cases by high throughput sequencing

Espasa A, Zamora L, Ribera JM.

Med Clin (Barc). 2020 Mar 18.

doi: 10.1016/j.medcli.2019.12.008.

Is sickle cell disease-related neurotoxicity a systemic endotheliopathy?

Udaeta MP, Diaz-Ricart M, Carreras E Hematol Oncol Stem Cell Ther 13 Mar 2020

DOI:10.1016/j.hemonc.2019.12.005